The drivers injuries are not thought to be life threatening.
Crews from Henley and Didcot Fire Station were called at 03:50am this morning to a vehicle that had left the A4130 near to Lower Assendon.
They worked for around 45 minutes to free the driver from the wreckage and into the care of the South Central Ambulance Service.
The cause of the crash is still being investigated by Thames Valley Police.
Incident commander Paul Herrington said:
"The driver was lucky to survive this high speed impact, the devastation was huge and the debris was all over the road when we arrived.
"We all need to take care when out on the roads, don’t drive tired or too fast and always wear a seatbelt".