Yoga, cooking and art classes are being put on digitally to prevent isolation during the pandemic.
Headway Oxfordshire, based Bagley Wood Road, Kennington, supports brain injury survivors, their families and carers.
The charity has launched a series of online interactive classes and activities which replicate the services usually on offer at the Activity and Rehabilitation Centre
It has temporarily closed its doors due to the coronavirus crisis, to help limit the spread of the virus.
The decision, along with having to postpone fundraising events has caused "financial challenges," according to Cheif Executive Jamie Millier.
Jamie said: "Rest assured, just because the doors to our centre are closed, it doesn't mean that we're not here to lend a listening ear, provide information and most importantly, be there for one another in these unsettling times.
"As a local charity, we are experiencing our own organisational and financial challenges as the coronavirus continues to put pressure on the care sector. Unfortunately, as yet there has been no Government support that Headway Oxfordshire has been eligible for.
"Many of our fundraising events have had to be postponed, which will have a huge impact on our financial situation, and in turn, on the services and support we are able to continue providing in the future.
"We're asking the people of Oxfordshire not to forget the charities out there working through this difficult time and if you can, please donate and help us to help those affected by brain injury across the county".
Headway Oxfordshire has also teamed up with food distribution charity SOFEA to deliver supplies to its most vulnerable Service User.