Oxford Health Charity is asking for donations like hand creams, energy bars and specialty teas.
The charity supports the Oxford Health NHS Foundation Trust; which runs physical and mental health services in its community hospitals.
The campaign aims to supply special packs to front-line staff who're giving round-the-clock care during the coronavirus pandemic.
The packs will be sent to 150 hubs across Oxfordshire, Buckinghamshire and Wiltshire to support some of the trusts 6,700 workers.
But, more organisations, businesses and the public are needed to offer donations.
Kerry Rogers is the Director of Corporate Affairs at the charity:
Kerry added: "We recognise the immense pressures our people are working under, the personal sacrifices they are making and the dedication they are demonstrating day and night to deliver the best care to all our patients and service users.
"They are our heroes on the frontline and we salute them."
Community Involvement Manager, Julie Pink, explained: "It's crucial during these times that our staff feel supported and these care packages will have treats to get them through their day or night shift - from teas and coffee to energy bars, soups and more.
"Over the coming weeks our hubs will support staff breaks, reminding our caring teams to stay hydrated and look after themselves.
"So if you can help with hand creams, lips balms, energy bars, drinks or any other item you think our teams would appreciate please contact me.
"I'd also like to thank all those who have helped for far including our friends at Restore and Carpenter Catering. Thank you so much.
If you can't donate items, you can make a big difference by donating via our charity website."
Julie added: "We must stand by our staff at this time and help them to deliver the care we all need. Please help us to reward our heroes, they deserve it."